High-Protein Pizza Breakfast Casserole

Featured in: Cozy Everyday Meals

This satisfying morning casserole combines a simple two-ingredient Greek yogurt dough with a fluffy egg layer, melted mozzarella and cheddar, plus turkey pepperoni for a pizza-inspired twist. Each serving delivers 22 grams of protein, making it ideal for meal prep or feeding a hungry crowd. The dough comes together quickly—just flour and Greek yogurt—while the egg mixture stays light and custard-like. Bake until golden and bubbly, then let rest briefly for clean slices.

Updated on Tue, 10 Feb 2026 10:19:40 GMT
Freshly baked High-Protein Pizza Breakfast Casserole with golden cheese, turkey pepperoni, and fluffy eggs on a crispy Greek yogurt crust. Save
Freshly baked High-Protein Pizza Breakfast Casserole with golden cheese, turkey pepperoni, and fluffy eggs on a crispy Greek yogurt crust. | meanwhilerecipe.com

Start your morning with a savory twist on a classic favorite. This High-Protein Pizza Breakfast Casserole is a game-changer for anyone looking to combine the comfort of pizza with the nutritional needs of a high-protein diet. Featuring a clever Greek yogurt dough base and a fluffy egg topping, it is a satisfying meal that works perfectly for a weekend brunch or as a prepared breakfast for busy weekdays.

Freshly baked High-Protein Pizza Breakfast Casserole with golden cheese, turkey pepperoni, and fluffy eggs on a crispy Greek yogurt crust. Save
Freshly baked High-Protein Pizza Breakfast Casserole with golden cheese, turkey pepperoni, and fluffy eggs on a crispy Greek yogurt crust. | meanwhilerecipe.com

Making a healthy breakfast doesn't mean you have to sacrifice flavor. By using turkey pepperoni and reduced-fat cheeses, you get all the zesty, melty goodness of a traditional pizza while keeping the macros in check. The Greek yogurt in the crust not only adds protein but also creates a tender, slightly tangy base that pairs beautifully with the seasoned egg mixture.

Ingredients

  • For the Greek Yogurt Dough:
  • 1 ½ cups (180 g) all-purpose flour
  • 2 teaspoons baking powder
  • ½ teaspoon salt
  • 1 cup (240 g) plain Greek yogurt (nonfat or 2%)
  • Toppings:
  • 8 large eggs
  • ½ cup (120 ml) low-fat milk
  • 1 cup (100 g) shredded part-skim mozzarella cheese
  • ½ cup (50 g) shredded reduced-fat cheddar cheese
  • ½ cup (60 g) turkey pepperoni slices
  • ½ teaspoon dried oregano
  • ½ teaspoon garlic powder
  • ¼ teaspoon black pepper
  • 2 tablespoons chopped fresh parsley (optional)
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Instructions

Step 1
Preheat your oven to 375°F (190°C). Lightly grease a 9x13-inch (23x33 cm) sheet pan or casserole dish.
Step 2
In a medium bowl, whisk together the flour, baking powder, and salt. Add the Greek yogurt and mix with a spoon until a shaggy dough forms. Knead briefly until smooth.
Step 3
Press the dough evenly into the prepared pan, forming a thin base.
Step 4
In a large bowl, whisk together the eggs, milk, oregano, garlic powder, and black pepper until well combined.
Step 5
Pour the egg mixture evenly over the dough base.
Step 6
Sprinkle both mozzarella and cheddar cheeses over the eggs. Top with turkey pepperoni slices.
Step 7
Bake for 20–25 minutes, or until the eggs are set and the cheese is golden and bubbly.
Step 8
Let cool for 5 minutes, then garnish with fresh parsley if desired. Slice and serve warm.

Zusatztipps für die Zubereitung

To ensure the dough is easy to handle, lightly flour your hands before pressing it into the pan. Making sure the egg mixture is poured slowly will help prevent it from splashing over the edges of the crust. For the best results, use a metal sheet pan for a crispier bottom crust.

Varianten und Anpassungen

This recipe is highly versatile; you can add diced bell peppers, mushrooms, or spinach for extra nutrition and flavor. If you prefer a different meat, substitute the turkey pepperoni with cooked chicken sausage or vegetarian pepperoni slices.

Serviervorschläge

For a true pizza experience, serve your casserole with a side of warm marinara sauce for dipping. It also pairs excellently with a light side salad or fresh fruit for a well-rounded morning meal.

A slice of High-Protein Pizza Breakfast Casserole shows melted mozzarella and cheddar on a fluffy egg topping for an easy meal prep. Save
A slice of High-Protein Pizza Breakfast Casserole shows melted mozzarella and cheddar on a fluffy egg topping for an easy meal prep. | meanwhilerecipe.com

With its high protein content and savory flavor profile, this Pizza Breakfast Casserole is bound to become a staple in your rotation. Enjoy the convenience of a delicious, prepped breakfast that tastes just as good as a fresh slice of pizza!

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Recipe FAQ

Can I make this ahead of time?

Yes, assemble everything the night before and refrigerate unbaked. Add 5-10 minutes to the cooking time when baking from cold.

What vegetables work well in this casserole?

Diced bell peppers, mushrooms, spinach, or onions add great flavor and nutrition. Sauté vegetables first to remove excess moisture.

Can I freeze leftovers?

Absolutely. Cut into individual portions, wrap tightly, and freeze for up to 3 months. Reheat in the microwave or oven.

Is the Greek yogurt dough really that simple?

Yes, just self-rising flour or all-purpose flour with baking powder plus plain Greek yogurt creates a surprisingly tender, pizza-like base.

What can I substitute for turkey pepperoni?

Try chicken sausage, vegetarian pepperoni, or cooked crumbled sausage. Even diced ham or bacon works beautifully.

How do I know when it's done baking?

The eggs should be completely set with no jiggle in the center, and the cheese should be golden and bubbling around the edges.

High-Protein Pizza Breakfast Casserole

Fluffy eggs and melted cheese atop a tender Greek yogurt crust, topped with savory turkey pepperoni.

Time to Prepare
20 mins
Time to Cook
25 mins
Complete Time
45 mins
Created by Meanwhilerecipe Clara Bennett

Recipe Category Cozy Everyday Meals

Skill Level Easy

Cuisine Type American

Makes 6 Number of Servings

Diet Considerations None specified

Ingredient List

Greek Yogurt Dough

01 1½ cups all-purpose flour
02 2 teaspoons baking powder
03 ½ teaspoon salt
04 1 cup plain Greek yogurt, nonfat or 2%

Toppings

01 8 large eggs
02 ½ cup low-fat milk
03 1 cup shredded part-skim mozzarella cheese
04 ½ cup shredded reduced-fat cheddar cheese
05 ½ cup turkey pepperoni slices
06 ½ teaspoon dried oregano
07 ½ teaspoon garlic powder
08 ¼ teaspoon black pepper
09 2 tablespoons chopped fresh parsley, optional

Steps

Step 01

Prepare Pan and Preheat Oven: Preheat oven to 375°F. Lightly grease a 9x13-inch sheet pan or casserole dish.

Step 02

Mix Dough Base: In a medium bowl, whisk together flour, baking powder, and salt. Add Greek yogurt and mix with a spoon until shaggy dough forms. Knead briefly until smooth.

Step 03

Layer Dough Foundation: Press dough evenly into prepared pan, forming a thin, uniform base.

Step 04

Prepare Egg Mixture: In a large bowl, whisk together eggs, milk, oregano, garlic powder, and black pepper until well combined.

Step 05

Add Egg Layer: Pour egg mixture evenly over dough base.

Step 06

Top with Cheese and Pepperoni: Sprinkle mozzarella and cheddar cheese over eggs. Distribute turkey pepperoni slices evenly across surface.

Step 07

Bake Until Golden: Bake for 20-25 minutes until eggs are set and cheese is golden and bubbly.

Step 08

Cool and Finish: Let cool for 5 minutes. Garnish with fresh parsley if desired. Slice and serve warm.

Tools Needed

  • 9x13-inch sheet pan or casserole dish
  • Mixing bowls, medium and large
  • Whisk
  • Measuring cups and spoons
  • Knife and cutting board

Allergy Notes

Examine all food items for allergens and consult your doctor for concerns.
  • Contains wheat gluten
  • Contains eggs
  • Contains dairy milk
  • Check turkey pepperoni and cheese labels for additional potential allergens

Nutrition Info (per portion)

These details are meant for reference, not as a substitute for medical guidance.
  • Energy (Calories): 260
  • Fats: 10 g
  • Carbohydrates: 19 g
  • Proteins: 22 g